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Dose:

Middle-aged men are invited to 20 mg at least 16 minutes before sexual activity with or without food. Patients can seek sex at any time during the 36 hours following receipt of a response time for optimal tadalfila. Until the frequency of administration - 1 times / day.


Overdose: No data
Drug Interactions:

Tadalafil is predominantly metabolised by CYP3A4. Selective CYP3A4 inhibitor ketoconazole increased the AUC by 107%, and rifampicin, is reduced to 88%.

Although specific interactions have been studied, we can assume that protease inhibitors such as ritonavir and saquinavir, as well as inhibitors of CYP3A4 such as erythromycin and itraconazole, increase the activity of tadalafil.

At the same time the antacid (magnesium hydroxide / aluminum hydroxide) and tadalafil reduced without changing the absorption AUC.

buy Cialis enhances the hypotensive effects of nitrates. This is due to the cumulative effects of nitrates and tadalafil nitric oxide and cGMP. Therefore, the tadalfila use in patients treated with nitrates, not recommended against.

Important information which is not always pay enough attention when taking medication. If two or more drugs may intensify or weaken the other. In the first case does not have the desired impact in medicine, while the other - the risk of lead poisoning, or overdose.

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When using a single dose in healthy volunteers and 500 mg of tadalafil tadalafil repeated use in patients with erectile dysfunction is 100 mg daily, adverse events were similar to those using a low dose. In case of overdose should be applied to the standard treatment of symptoms.
Its removal by hemodialysis tadalafil effect negligible.

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